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Neurotechnology Translation Readiness Assessment

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About This Assessment

A seven-requirement framework for early assessment of clinical and commercial viability of proposed new neurotechnologies.

The Seven Requirements

  1. Incremental Benefit - Clinical value compared to existing solutions
  2. Acceptable Cost/Risk - Cost-effectiveness and risk profile
  3. Practicality - Ease of use and workflow integration
  4. Reliability - Functional consistency and durability
  5. Supportive Ecosystem - Investment, IP, supply chain, and distribution
  6. Regulatory Approval - Path to regulatory clearance
  7. Commercial Viability - Business case and return on investment

Anna Karenina Principle

If any requirement receives the lowest possible score of 1, eventual success of the overall effort is unlikely. All requirements must be adequately satisfied for success.

Requirement I: Incremental Benefit

Assess the clinical benefit of your neurotechnology compared to current standard of care using the EQ-5D framework.

HUI Input Method

EQ-5D Assessment

Complete the questionnaire for both Standard of Care (SoC) and your proposed Neurotechnology solution.

Category Standard of Care Neurotechnology
Mobility
Self-Care
Usual Activities
Pain/Discomfort
Anxiety/Depression
SoC Health State Profile
11111
HUI: 1.000
Neurotech Health State Profile
11111
HUI: 1.000
Potential Incremental Benefit (PIB)
0
No improvement
Enter all assumptions and references necessary to support your choices above.
-

Requirement I Score (R-I)

Complete the assessment above

Requirement II: Acceptable Cost/Risk

Evaluate whether the incremental cost is justified by the incremental benefit using Cost-Utility Analysis (CUA).

Incremental Benefit (QALY) - From Requirement I

These values are automatically transferred from your Requirement I assessment.

To change HUI values, go back to Requirement I and adjust the EQ-5D assessment/direct HUI entries.

Risk Adjustment

Incremental Cost

Willingness to Pay Threshold

Adjusted Delta QALY
0.045
Adjusted Delta Cost
$40,250
ICER
$894,444/QALY
Enter all assumptions and references necessary to support your choices above.
-

Requirement II Score (R-II)

Based on cost-utility analysis quadrant

Requirement III: Practicality

Assess the degree to which users, caregivers, or the environment experience challenges during setup or operation.

Enter all assumptions and references necessary to support your choices above.
-

Requirement III Score (R-III)

Average of 9 practicality criteria (rounded)

Requirement IV: Reliability

Assess the reliability of the neurotechnology in both short and long term.

Enter all assumptions and references necessary to support your choices above.
-

Requirement IV Score (R-IV)

Average of 4 reliability criteria (rounded)

Requirement V: Supportive Ecosystem

Assess the practicality of developing the neurotechnology and introducing it into its intended environment.

Enter all assumptions and references necessary to support your choices above.
-

Requirement V Score (R-V)

Average of 5 ecosystem criteria (rounded)

Requirement VI: Regulatory Approval

Assess the challenges associated with obtaining regulatory approval based on precedent.

Regulatory Precedent

Enter all assumptions and references necessary to support your choices above.
-

Requirement VI Score (R-VI)

Based on regulatory precedent

Requirement VII: Commercial Viability

Assess whether there is enough financial incentive to motivate investment in this neurotechnology.

Market & Revenue

Development Stage & Risk

Investment

Adjustments

Net Future Value
$2.0B
Risk-adjusted NPV
$281M
ROI
2.53x
Enter all assumptions and references necessary to support your choices above.
-

Requirement VII Score (R-VII)

Based on calculated ROI

Overall Assessment

-
Complete all requirements to see results
-

I. Incremental Benefit

Not assessed

-

II. Cost/Risk

Not assessed

-

III. Practicality

Not assessed

-

IV. Reliability

Not assessed

-

V. Ecosystem

Not assessed

-

VI. Regulatory

Not assessed

-

VII. Commercial

Not assessed

Radar Chart

Export Results

Download your assessment results for reporting or further analysis.

Project Conclusion (Optional)